4-Chloro-8-(trifluoromethyl)quinoline → 4-(5-fluoro-2-methyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline

HRID 418442

Reaktionsgleichung

Reaktionsgleichung von HRID 418442
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[CH:5]2.Cl[C:13]1[C:22]2[C:17](=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[C:5]2[C:13]1[C:22]2[C:17](=[C:18]([C:23]([F:26])([F:24])[F:25])[CH:19]=[CH:20][CH:21]=2)[N:16]=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 902624-Chloro-8-(trifluoromethyl)quinolineHCID 27787155-Fluoro-2-methylindole

Produkt 1

HCID 684584344-(5-fluoro-2-methyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline

Versuchsvorschrift

The sub-title compound was prepared from 5-fluoro-2-methylindole and 4-chloro-8-trifluoromethylquinoline by the method of Example 31, step a).

Quellen und Nachweise

ORD-Eintrag
ord-85f86c59b6a1488f88f169a476f79f6e
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093278B2

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