N1-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-(2-methoxyphenyl)malonamide → N1-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-5-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-(2-methoxyphenyl)malonamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N1-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-(2-methoxyphenyl)malonamide	HCID 16040869	—
Edukt	3-Fluoro-4-(2-(1-methyl-1H-imidazol-5-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine	HCID 59424431	—
Produkt	N1-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-5-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-(2-methoxyphenyl)malonamide	HCID 16040871	24%

Reaktionsschritte

Following the procedure described above for the compound 28a (example 8, step 2) but replacing amine 9 for amine 18, title compound 28c was obtained in 24% yield. 1H NMR (DMSO-d6) δ (ppm): 10.58 (s, 1H), 9.62 (s, 1H), 8.49 (d, 1H), 8.05 (dd, 1H), 7.85 (m, 2H), 7.77 (s, 1H), 7.48 (t, 1H), 7.41 (m, 2H), 7.05 (m, 2H), 6.90 (m, 2H) 6.63 (dd, 1H), 3.88 (s, 3H), 3.84 (s, 3H), 3.63 (s, 2H). MS (m/z): 531.8 (M+H).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08093264B2
Quelldatensatz	uspto-grants-2012_01
ORD ID	ord-3c13b45f3946450a93bef49a97e20c28
Quellennotiz	uspto-grants-2012_01