Ethyl 2-(3-Fluoro-4-(2-(3-methoxy-4-(2-morpholinoethoxy)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetate → Ethyl 2-(3-fluoro-4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetate

HRID 418648Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 418648
[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[S:16][C:15]3[C:10](=[N:11][CH:12]=[CH:13][C:14]=3[O:17][C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][C:19]=3[F:25])[CH:9]=2)[N:5]=[CH:4]1)[CH3:2].FC1C=C(N[C:61](=[O:67])[C:62]([O:64][CH2:65][CH3:66])=[O:63])C=CC=1OC1C=CN=C2C=C(C3C=CC(OCCN4CCOCC4)=C(OC)C=3)SC=12>>[F:25][C:19]1[CH:20]=[C:21]([NH:24][C:61](=[O:67])[C:62]([O:64][CH2:65][CH3:66])=[O:63])[CH:22]=[CH:23][C:18]=1[O:17][C:14]1[CH:13]=[CH:12][N:11]=[C:10]2[CH:9]=[C:8]([C:6]3[N:5]=[CH:4][N:3]([CH2:1][CH3:2])[CH:7]=3)[S:16][C:15]=12

Komponenten

3

Edukt 2

HCID 58790158Ethyl 2-(3-Fluoro-4-(2-(3-methoxy-4-(2-morpholinoethoxy)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetateHCID 594244554-(2-(1-Ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine

Produkt 1

HCID 58790366Ethyl 2-(3-fluoro-4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-2-oxoacetateAusbeute 14 %

Versuchsvorschrift

Starting from the amine 15 (scheme 4) and following the same procedure as described for the synthesis of compound 140 (scheme 40), title compound 142 was obtained as white solid in 14% yield. MS (m/z): 455.1 (M+H).

Quellen und Nachweise

ORD-Eintrag
ord-41876b7db3d04eb4a49bd06ee0cb2a10
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093264B2

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