Vorinostat → N-hydroxy-N'-phenyloctanediamide vorinostat

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

The seed slurry is prepared by combining vorinostat-fine dry cake (97.8-116.3 g, 0.37-0.44 mol) and 50:50 (v/v) ethanol/water solution (1.0-1.2 L). Under a minimum of 15 psig pressure, the seed slurry is heated to 62-66° C., aged for about 0.5 hours and then cooled to 60-64° C.

Herkunft & Nachweise