Tetrahydrofuran → HCID 57912422, Verbindung

HRID 418870Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 418870
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:16][C:15]3[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=3[O:13][CH:12]=2)=[CH:7][CH:6]=1)(=O)C.C1COCC1.C([O-])([O-])=O.[K+].[K+]>CO>[O:16]1[C:11]([C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=2)=[CH:12][O:13][C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]1=2

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 11430Potassium CarbonateHCID 57912410HCID 57912410, Verbindung

Produkt 1

HCID 57912422HCID 57912422, VerbindungAusbeute 77,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-(benzo[b][1,4]dioxin-2-yl)phenyl acetate (270 mg, 1.0 mmol) in MeOH:THF (5 mL: 3 mL) and K2CO3 (167 mg, 1.2 mmol) was stirred for 30 min at rt. The solvent was removed under reduced pressure and water was added. The solution was neutralized by dilute HCl and the solid was isolated by filtration, washed well with water and dried to give 175 mg of 4-(benzo[b][1,4]dioxin-2-yl)phenol (77%). MS (ES) m/z: 225.97 (M), 224.93 (M−1); Mp. 137-140° C.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure and water
  2. additionwas added
  3. customthe solid was isolated by filtration
  4. washwashed well with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3b096b12d41b46a097f66f621040daa8
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093273B2

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