Acetophenone → (E)-N-[(4-nitrophenyl)methoxy]-1-phenylethanimine
Reaktionsgleichung
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=O)[CH3:2].Cl.[N+:11]([C:14]1[CH:22]=[CH:21][C:17]([CH2:18][O:19][NH2:20])=[CH:16][CH:15]=1)([O-:13])=[O:12]>>[N+:11]([C:14]1[CH:15]=[CH:16][C:17]([CH2:18][O:19]/[N:20]=[C:1](/[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)\[CH3:2])=[CH:21][CH:22]=1)([O-:13])=[O:12]Komponenten
3
Versuchsvorschrift
Acetophenone (20) (150 mg, 1.25 mmol) was condensed with compound 19 (280 mg, 1.37 mmol) according to the general procedure II-A defined above. After heating the reaction mixture for 2 h it was cooled and the solvent removed under reduced pressure. The resulting solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30252 (258 mg, 77%) as a pale-yellow solid, m.p. 91.3-92.3° C.
Aufarbeitung
- temperatureAfter heating the reaction mixture for 2 h it
- temperature