3,4-Dimethoxyphenyl methyl ketone → (E)-1-(3,4-dimethoxyphenyl)-N-[(4-nitrophenyl)methoxy]ethanimine
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11](=O)[CH3:12])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.[N+:15]([C:18]1[CH:26]=[CH:25][C:21]([CH2:22][O:23][NH2:24])=[CH:20][CH:19]=1)([O-:17])=[O:16]>>[N+:15]([C:18]1[CH:19]=[CH:20][C:21]([CH2:22][O:23]/[N:24]=[C:11](/[C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)\[CH3:12])=[CH:25][CH:26]=1)([O-:17])=[O:16]Komponenten
3
Versuchsvorschrift
3′,4′-Dimethoxyacetophenone (23) (150 g, 0.832 mmol) was condensed with compound 19 (187 mg, 0.914 mmol) according to the general procedure II-A defined above. After being heated for 3 h the mixture was cooled and the resulting solid filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30257 (222 mg, 81%) as a white solid, m.p. 118.4-121.0° C.
Aufarbeitung
- temperatureAfter being heated for 3 h the mixture