1-(3-Hydroxy-4-methoxyphenyl)ethanone → 5-[(E)-N-[(4-fluorophenyl)methoxy]-C-methylcarbonimidoyl]-2-methoxyphenol

HRID 41937

Reaktionsgleichung

Reaktionsgleichung von HRID 41937
[OH:1][C:2]1[CH:3]=[C:4]([C:10](=O)[CH3:11])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].Cl.[F:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][O:20][NH2:21])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][O:20]/[N:21]=[C:10](/[C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([OH:1])[CH:3]=2)\[CH3:11])=[CH:17][CH:16]=1

Komponenten

3

Edukt 2

HCID 956931-(3-Hydroxy-4-methoxyphenyl)ethanoneHCID 12800721o-(4-Fluorobenzyl)hydroxylamine hydrochloride

Produkt 1

HCID 251002525-[(E)-N-[(4-fluorophenyl)methoxy]-C-methylcarbonimidoyl]-2-methoxyphenolAusbeute 80,4 %

Versuchsvorschrift

Acetophenone 12 (50 mg, 0.301 mmol) was condensed with O-(4-fluorobenzyl)hydroxylamine hydrochloride (29) (58 mg, 0.327 mmol) according to the general procedure II-B defined above. After being heated for 24 h the reaction mixture was cooled and the solvent removed under reduced pressure. The ensuing residue was dissolved in CH2Cl2 (15 mL) and the resulting solution washed with H2O (2×10 mL) then dried (MgSO4), filtered and concentrated under reduced pressure. The oil thus obtained was subjected to flash chromatography (1:19 v/v ethyl acetate/hexane elution) to afford the title compound CP30266 (70 mg, 80%) as a pale-purple waxy-oil, Rf 0.5 in 1:1 v/v ethyl acetate/hexane.

Aufarbeitung

  1. temperatureAfter being heated for 24 h the reaction mixture
  2. temperaturewas cooled
  3. customthe solvent removed under reduced pressure
  4. dissolutionThe ensuing residue was dissolved in CH2Cl2 (15 mL)
  5. washthe resulting solution washed with H2O (2×10 mL)
  6. dry with materialthen dried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customThe oil thus obtained
  10. washwas subjected to flash chromatography (1:19 v/v ethyl acetate/hexane elution)

Quellen und Nachweise

ORD-Eintrag
ord-33a86ec32c7f452895ed1319b948ae9d
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536157B2

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