Methylamine → ([2-(Methylamino)ethyl]sulfonyl)benzene

HRID 4201

Reaktionsgleichung

Reaktionsgleichung von HRID 4201
Cl[CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH3:13][NH2:14]>C(#N)C>[CH3:13][NH:14][CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 13646((2-Chloroethyl)sulphonyl)benzene

Produkt 1

HCID 5152138([2-(Methylamino)ethyl]sulfonyl)benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.

Aufarbeitung

  1. customThe solvent is removed in vacuo
  2. customthe residue is partitioned between methylene chloride and dilute sodium hydroxide
  3. extractionThe methylene chloride solution is extracted with dilute sulfuric acid
  4. extractionThe acidic extract
  5. extractionthe basic solution is extracted with methylene chloride
  6. dry with materialThe methylene chloride solution is dried over magnesium sulfate
  7. customthe solvent is removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ae4c77ae86b04fcaa9012d4cce7a5a3a
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04724235

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