Hydrochloric Acid → 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid

HRID 420143Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 420143
[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:18][CH3:19])[CH:9]=[C:10]([C:13]([O:15]CC)=[O:14])[CH:11]=3)[CH:6]=[CH:5]2)[CH2:3][CH2:2]1.Cl>CO>[CH:1]1([N:4]2[C:12]3[C:7](=[C:8]([O:18][CH3:19])[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=3)[CH:6]=[CH:5]2)[CH2:2][CH2:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 66649481ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate

Produkt 1

HCID 666494031-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acidAusbeute 102,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

35 ml of 5N NaOHaq was added to a solution of 15.15 g of ethyl 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylate in MeOH and the mixture was stirred at 60° C. for 8 hrs. The mixture was cooled to 0° C. and 35 ml of 5N HCl was added thereto. The precipitate was filtered and dried in vacuo to give 13.8 g of 1-cyclopropyl-4-methoxy-1H-indole-6-carboxylic acid as a colorless solid.

Aufarbeitung

  1. temperatureThe mixture was cooled to 0° C.
  2. filtrationThe precipitate was filtered
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2658d04a79664bfc89460908213bc932
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093389B2

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