HCID 178451554, Verbindung → HCID 178515376, Verbindung

HRID 420151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 420151
[O:1]=[C:2]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:24]3[NH:28][N:27]=[N:26][N:25]=3)[CH:22]=2)[O:17][C:4]2([CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2)[CH2:3]1>Cl.O1CCOCC1>[NH:28]1[C:24]([C:21]2[CH:22]=[C:23]3[C:18](=[CH:19][CH:20]=2)[O:17][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][C:2]3=[O:1])=[N:25][N:26]=[N:27]1

Komponenten

3

Edukt 1

HCID 178451554HCID 178451554, Verbindung

Produkt 1

HCID 178515376HCID 178515376, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 204431481,4-Dioxane hydrochlorideLösungsmittel

Versuchsvorschrift

4 N HCl-1,4-dioxane (200 mL) was added to 40.6 g tert-butyl 4-oxo-6-(1H-tetrazol-5-yl)spiro[chroman-2,4′-piperidine]-1′-carboxylate produced in Reference Example 17, and stirred at room temperature for 5 hours. The reaction mixture was concentrated, and the residue was triturated with methanol. The insoluble solid was collected through filtration, and dried under reduced pressure to obtain 6-(1H-tetrazol-5-yl)-spiro[chroman-2,4′-piperidine]-4-one as a colorless solid.

Aufarbeitung

  1. customproduced in Reference Example 17
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was triturated with methanol
  4. filtrationThe insoluble solid was collected through filtration
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-498688e63a1e444296f256c3e128be1b
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08093389B2

Notizen zur Reaktion

Wird geladen…