Anthranilic Acid → Ethyl 2-aminobenzoate

HRID 42036

Reaktionsgleichung

Reaktionsgleichung von HRID 42036
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH2:16](O)[CH3:17]>>[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]

Komponenten

4

Edukt 3

HCID 227Anthranilic AcidHCID 702EthanolHCID 1118Sulfuric Acid

Produkt 1

HCID 6877Ethyl 2-aminobenzoateAusbeute 78 %

Versuchsvorschrift

To a solution of 2-aminobenzoic acid (7.29 mmol, 1.0 g) in ethanol (20 ml), H2SO4 (45 mmol, 2.5 ml) was added and the mixture was refluxed for 20 hours. The solvent was evaporated and the crude residue was dissolved in water. The solution neutralised with 6N NaOH aqueous solution and extracted with CHCl3. The organic phase was evaporated affording 0.939 g (yield 78%) of the expected product.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 20 hours
  2. customThe solvent was evaporated
  3. dissolutionthe crude residue was dissolved in water
  4. extractionextracted with CHCl3
  5. customThe organic phase was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-4b37735ad9534962a4502eed81159ae0
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536165B2

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