Anthranilic Acid → Ethyl 2-aminobenzoate
Reaktionsgleichung
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH2:16](O)[CH3:17]>>[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]Komponenten
4
Versuchsvorschrift
To a solution of 2-aminobenzoic acid (7.29 mmol, 1.0 g) in ethanol (20 ml), H2SO4 (45 mmol, 2.5 ml) was added and the mixture was refluxed for 20 hours. The solvent was evaporated and the crude residue was dissolved in water. The solution neutralised with 6N NaOH aqueous solution and extracted with CHCl3. The organic phase was evaporated affording 0.939 g (yield 78%) of the expected product.
Aufarbeitung
- temperaturethe mixture was refluxed for 20 hours
- customThe solvent was evaporated
- dissolutionthe crude residue was dissolved in water
- extractionextracted with CHCl3
- customThe organic phase was evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-4b37735ad9534962a4502eed81159ae0
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08536165B2
Notizen zur Reaktion
Wird geladen…