Methanol → Methyl 2-chloro-4-methylbenzoate

HRID 420753

Reaktionsgleichung

Reaktionsgleichung von HRID 420753
[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].O=S(Cl)Cl.[CH3:16]O>>[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:16])=[O:5]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 27357552-Chloro-4-methylbenzoic acid

Produkt 1

HCID 22019481Methyl 2-chloro-4-methylbenzoate

Versuchsvorschrift

2-chloro-4-methylbenzoic acid (500 mg, 2.93 mmol) was dissolved in Methanol (7 mL) and SOCl2 (0.215 mL, 2.93 mmol) was slowly added to the mixture and the reaction was left at room temperature overnight. Next morning HPLC showed completion. Volatiles were removed under vacuum to afford 526 mg of the title compound as brown oil.

Aufarbeitung

  1. customVolatiles were removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-816d5ce1e99a4848bd036311ac824933
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08097628B2

Verknüpfte Notizen

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