Trifluoroacetic acid → 5-[6-Morpholin-4-yl-8-piperazin-1-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl]pyrimidin-2-amine trifluoroacetate

HRID 421377

Reaktionsgleichung

Reaktionsgleichung von HRID 421377
[N:1]1([C:7]2[N:15]=[C:14]([C:16]3[CH:17]=[N:18][C:19]([NH:22]C(=O)OC(C)(C)C)=[N:20][CH:21]=3)[N:13]=[C:12]3[C:8]=2[N:9]=[C:10]([N:35]2[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]2)[N:11]3[CH2:30][C:31]([F:34])([F:33])[F:32])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44]>C(Cl)Cl>[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].[N:1]1([C:7]2[N:15]=[C:14]([C:16]3[CH:17]=[N:18][C:19]([NH2:22])=[N:20][CH:21]=3)[N:13]=[C:12]3[C:8]=2[N:9]=[C:10]([N:35]2[CH2:36][CH2:37][NH:38][CH2:39][CH2:40]2)[N:11]3[CH2:30][C:31]([F:32])([F:34])[F:33])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59333500tert-Butyl{5-[6-morpholin-4-yl-8-piperazin-1-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl]pyrimidin-2-yl}carbamate

Produkt 1

HCID 866419965-[6-Morpholin-4-yl-8-piperazin-1-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl]pyrimidin-2-amine trifluoroacetateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

tert-Butyl {5-[6-morpholin-4-yl-8-piperazin-1-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl]pyrimidin-2-yl}carbamate (1.18 g, 2.09 mmol) was dissolved in methylene chloride (10 ml) followed by the addition of trifluoroacetic acid (10 ml) with ice cooling and the resulting mixture was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure followed by the addition of toluene and evaporated again under reduced pressure to give the title compound (1.5 g, 100%) as a yellow solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. additionfollowed by the addition of toluene
  3. customevaporated again under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e5def6fe16124d7885a8da89e40722da
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08097622B2

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