Nitric Acid → Quetiapine Nitrate

HRID 421567

Reaktionsgleichung

Reaktionsgleichung von HRID 421567
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[N+:28]([O-:31])([OH:30])=[O:29]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[N+:28]([O-:31])([O-:30])=[O:29]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 5002Quetiapine

Produkt 1

HCID 86647094Quetiapine NitrateAusbeute 80,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Quetiapine free base (5.0 g) was dissolved in acetone (50 ml) at room temperature. This was followed by the addition of 68 to 72% nitric acid (0.7 g) at 20 to 25° C. The resulting precipitated solid was stirred for 1 hour. The precipitated product was collected by filtration, washed with acetone (15 ml) and dried to give the title compound as white powder (4.0 g).

Aufarbeitung

  1. customThe resulting precipitated solid
  2. filtrationThe precipitated product was collected by filtration
  3. washwashed with acetone (15 ml)
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bf4fd07b135d4045b967766573be7751
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101597B2

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