Quetiapine → HCID 131729402, Verbindung

HRID 421570

Reaktionsgleichung

Reaktionsgleichung von HRID 421570
[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([OH:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:49]=[CH:48][C:47]([CH3:50])=[CH:46][CH:45]=2)=[O:43])([OH:41])[C:38]([OH:40])=[O:39])=[O:35])=[CH:30][CH:29]=1>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:15][C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][O:24][CH2:25][CH2:26][OH:27])[CH2:18][CH2:17]3)[C:5]=2[CH:6]=1.[C:28]1([CH3:55])[CH:33]=[CH:32][C:31]([C:34]([C@@:36]([C:52]([O-:54])=[O:53])([OH:51])[C@@:37]([C:42]([C:44]2[CH:45]=[CH:46][C:47]([CH3:50])=[CH:48][CH:49]=2)=[O:43])([OH:41])[C:38]([O-:40])=[O:39])=[O:35])=[CH:30][CH:29]=1

Komponenten

4

Edukt 2

HCID 5002QuetiapineHCID 29414711Di-para-toluoyl-L-tartaric acid

Produkt 1

HCID 131729402HCID 131729402, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Quetiapine free base (3.0 g) was dissolved in acetone (30 ml) at room temperature. To this solution was added di-p-toluoyl-L-tartaric acid (1.52 g) at 30 to 35° C. The resulting mass heated to reflux and maintained for 30 minutes. This was followed by the distillation of acetone and obtained solid was further dried under vacuum to give the title compound as off white powder (3.62 g).

Aufarbeitung

  1. temperatureThe resulting mass heated
  2. temperatureto reflux
  3. temperaturemaintained for 30 minutes
  4. distillationThis was followed by the distillation of acetone
  5. customobtained solid
  6. customwas further dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-06dbf6660c6847878637dcbfbbfbcc4f
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101597B2

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