Trifluoroacetic acid → Trifluoroacetic acid

HRID 42183Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 42183
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)=[N:9][CH:10]=1)=[O:4].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:7][CH:6]=1)=[O:4].[C:26]([OH:28])([C:25]([F:30])([F:29])[F:24])=[O:27]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59240679Methyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylate

Produkt 2

HCID 6422Trifluoroacetic acidAusbeute 262,7 %HCID 57471612Methyl 2-(piperazin-1-yl)pyrimidine-5-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(4-tert-Butoxycarbonyl-piperazin-1-yl)-pyrimidine-5-carboxylic acid methyl ester (140 mg, 0.434 mmol) is dissolved in dichloromethane (3.0 mL) under N2. Trifluoroacetic acid (0.83 ml, 10.85 mmol) is added and the reaction mixture is stirred for 2 h. The reaction mixture is concentrated under reduced pressure and co-evaporated several times with dichloromethane. It is dried under high vacuum to afford the title compound as a TFA salt (130 mg, 90% yield).

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customIt is dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f0ad376f7fb445229dc8392f8c020b6f
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536168B2

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