Dimethylamine methanol → 1-(4,4-Dimethylpentanoyl)-4-{4-[5-(dimethylamino)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}piperazine

HRID 421843

Reaktionsgleichung

Reaktionsgleichung von HRID 421843
[CH3:1][C:2]([CH3:29])([CH3:28])[CH2:3][CH2:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([C:19]3[N:23]=[C:22](C(Cl)(Cl)Cl)[O:21][N:20]=3)[CH:16]=[CH:15][N:14]=2)[CH2:9][CH2:8]1)=[O:6].[CH3:30][NH:31][CH3:32].CO>CO>[CH3:1][C:2]([CH3:29])([CH3:28])[CH2:3][CH2:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[C:17]([C:19]3[N:23]=[C:22]([N:31]([CH3:32])[CH3:30])[O:21][N:20]=3)[CH:16]=[CH:15][N:14]=2)[CH2:9][CH2:8]1)=[O:6]

Komponenten

4

Edukt 2

HCID 22497844Dimethylamine methanolHCID 666737671-(4,4-Dimethylpentanoyl)-4-{4-[5-(trichloromethyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}piperazine

Produkt 1

HCID 119931871-(4,4-Dimethylpentanoyl)-4-{4-[5-(dimethylamino)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1-(4,4-Dimethylpentanoyl)-4-{4-[5-(trichloromethyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}piperazine (48.1 mg) was dissolved in methanol (2 mL), and 2.0 M dimethylamine/methanol solution (1 mL) was added thereto and stirred at room temperature for 2 hours. Then, the solvent was evaporated away and the resulting residue was isolated and purified through thin-layer silica gel chromatography (hexane/ethyl acetate=1/1) to obtain 17.5 mg of the entitled compound as a yellow oil.

Aufarbeitung

  1. customThen, the solvent was evaporated away
  2. customthe resulting residue was isolated
  3. custompurified through thin-layer silica gel chromatography (hexane/ethyl acetate=1/1)

Quellen und Nachweise

ORD-Eintrag
ord-929b559e0a4a45d289c8eaf60911fd45
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101618B2

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