HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl 6-chloronicotinate → Ethyl 6-[(2R)-2-methyl-4-[4-(phenylmethyl)-1-phthalazinyl]-1-piperazinyl]-3-pyridinecarboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl 6-chloronicotinate | HCID 2799611 | — |
| Edukt | 1-Benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine | HCID 44186248 | — |
| Produkt | Ethyl 6-[(2R)-2-methyl-4-[4-(phenylmethyl)-1-phthalazinyl]-1-piperazinyl]-3-pyridinecarboxylate | HCID 59240661 | 71,1% |
Reaktionsschritte
Following the above procedure, 6-chloronicotinic acid ethyl ester (100 mg, 0.54 mmol, 1.7 eq) and 1-benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine (100 mg, 0.31 mmol, 1.0 eq) afford the title compound as a white solid (103 mg, 71% yield).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08536168B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-526bb1fb44604fb196db5f4a9db53633 |
| Quellennotiz | uspto-grants-2013_09 |