Hydrochloric Acid → 3-Chloro-2-cyanobenzoic acid

HRID 421994Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 421994
C[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:11]#[N:12])[C:3]=1[Cl:13].[OH-].[Na+].Cl>CO>[Cl:13][C:3]1[C:4]([C:11]#[N:12])=[C:5]([CH:9]=[CH:10][CH:2]=1)[C:6]([OH:8])=[O:7]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66676571Methyl 3-chloro-2-cyanobenzoic acid

Produkt 1

HCID 533972953-Chloro-2-cyanobenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The mixture of 430 mg of methyl 3-chloro-2-cyanobenzoic acid obtained by the same manner as in U.S. Pat. No. 4,900,739, 22 ml of methanol and 2.5 ml of aqueous sodium hydroxide (1 mol/l) was stirring at room temperature for 2 hours. To the reaction mixture was added hydrochloride (5 mol/l) and was extracted with chloroform. The organic layer was washed with water and saturated brine, and then dried over magnesium sulfate. The organic layer was filtered and concentrated in vacuo to give the title compound.

Aufarbeitung

  1. customobtained by the same manner as in U.S
  2. extractionwas extracted with chloroform
  3. washThe organic layer was washed with water and saturated brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationThe organic layer was filtered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bdf338e722c146889b2ab6f5cf116b09
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101621B2

Notizen zur Reaktion

Wird geladen…