2-Chloromethyl-imidazo(1,2-A)pyridine → Imidazo(1,2-a)pyridine

HRID 422278Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 422278
ClC[C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1>C([O-])(O)=O.[Na+]>[N:4]1[CH:3]=[CH:11][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12

Komponenten

3

Edukt 1

HCID 9576142-Chloromethyl-imidazo(1,2-A)pyridine

Produkt 1

HCID 78960Imidazo(1,2-a)pyridineAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 516892Sodium BicarbonateLösungsmittel

Versuchsvorschrift

To saturated NaHCO3 (40 mL) was added the chlorhydrate form of 2-(chloromethyl)-imidazo[1,2-a]pyridine and the aqueous layer was extracted with AcOEt. The organic layers were combined and washed with brine, dried over MgSO4 and the solvent was removed under reduced pressure to afford 877 mg of 2-chloromethyl)-imidazo[1,2-a]pyridine (Yield. 80%) as a brownish solid (M.P.: 8485° C.)

Aufarbeitung

  1. extractionthe aqueous layer was extracted with AcOEt
  2. washwashed with brine
  3. dry with materialdried over MgSO4
  4. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-87acddfc0a9e4ecc9b0e7604d463773c
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101637B2

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