Potassium Carbonate → 3-[1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-1H-indole

HRID 42233

Reaktionsgleichung

Reaktionsgleichung von HRID 42233
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].[F:22][C:23]([F:32])([F:31])[C:24]1[CH:25]=[CH:26][C:27](Cl)=[N:28][CH:29]=1>CN(C=O)C>[NH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([CH:4]2[CH2:5][CH2:6][N:1]([C:27]3[CH:26]=[CH:25][C:24]([C:23]([F:32])([F:31])[F:22])=[CH:29][N:28]=3)[CH2:2][CH2:3]2)=[CH:8]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 7022353-(4-Piperidinyl)-1H-indole

Produkt 1

HCID 49985353-[1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

3-piperidin-4-yl-1H-indole (0.5 g, 2.5 mmol) is suspended in 10 ml of DMF and is heated to 60° C. K2CO3 and 5-trifluoromethyl-2-chloropyridine (0.54 g, 3.0 mmol) are added and the reaction mixture is stirred at 95° C. for 1 hour. K2CO3 is removed by filtration and the filtrate is concentrated and purified with a silica gel flash column using heptane and ethyl acetate as the elutes.

Aufarbeitung

  1. customK2CO3 is removed by filtration
  2. concentrationthe filtrate is concentrated
  3. custompurified with a silica gel flash column

Quellen und Nachweise

ORD-Eintrag
ord-8f6ee38d8838478296cd066b6acc8b7a
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536168B2

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