HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → 4-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | HCID 16086089 | — |
| Edukt | Phthalazine, 6-chloro-1-(2,2,2-trifluoro-1-methylethoxy)- | HCID 66675982 | — |
| Produkt | 4-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine | HCID 66675739 | — |
Reaktionsschritte
The title compound was prepared according to a procedure similar to that described in Example 225, using 6-chloro-1-(1,1,1-trifluoropropan-2-yloxy)phthalazine and 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine as starting materials. MS (ESI, pos. ion) m/z: 348.1 (M+1). The racemic material was subjected to Preparative SFC separation using a chiral column to afford its (R)- and (S)-enantiomers.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08101612B2 |
| Quelldatensatz | uspto-grants-2012_01 |
| ORD ID | ord-e31646723b8647f9bac97b0a8f9b1c35 |
| Quellennotiz | uspto-grants-2012_01 |