4-Chlorophenyl cyclopropyl ketone → (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Methoxylamine hydrochloride (2.004 g) was added to (4-chlorophenyl)(cyclopropyl)methanone (2.71 g) in pyridine (60 mL) at 25° C. The resulting solution was stirred at 25° C. for 24 hours. The pyridine was removed in vacuo, and the residual solid extracted with ether. Filtration and evaporation of the solvent gave the crude (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime (2.75 g, 87%) as a yellow oil. This material was used directly in the next step without further purification.

Herkunft & Nachweise