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HCID 58275259, Verbindung → HCID 58275500, Verbindung

HRID 42330
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 42330
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[C:13]([NH:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[CH:30][C:29]=4[C:38](F)(F)F)[N:14]=[C:15]([NH:18][C:19]4([C:22]([F:25])([F:24])[F:23])[CH2:21][CH2:20]4)[C:16]=3[N:17]=2)=[CH:4][CH:3]=1.ClC1C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.FC1C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.ClC1C=C(C(NC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C)C=CC=1S(N)(=O)=O.FC1C=C(CCNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=CC=1S(N)(=O)=O.ClC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1S(N)(=O)=O.FC1C=C(S(N)(=O)=O)C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=1.FC1C=CC(C2C=CC3N=C(NCC4C=CC(S(N)(=O)=O)=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.FC1C=CC(C2C=CC3N=C(NCCC4C=CC(S(N)(=O)=O)=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.FC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1NS(C)(=O)=O.FC1C=CC(C2C=CC3N=C(NCC4C=CC(C(F)(F)F)=C(NS(C)(=O)=O)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1.ClC1C=CC(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)=CC=1NS(C)(=O)=O.ClC1C=C(NS(C)(=O)=O)C=C(CNC2N=C(NC3(C(F)(F)F)CC3)C3N=C(C4C=CC(F)=CC=4)C=CC=3N=2)C=1.FC1C=CC(C2C=CC3N=C(NCC4C=C(NS(C)(=O)=O)C=C(C(F)(F)F)C=4)N=C(NC4(C(F)(F)F)CC4)C=3N=2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]=[C:13]([NH:26][CH2:27][C:28]4[CH:33]=[CH:32][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[CH:30][C:29]=4[CH3:38])[N:14]=[C:15]([NH:18][C:19]4([C:22]([F:23])([F:25])[F:24])[CH2:21][CH2:20]4)[C:16]=3[N:17]=2)=[CH:6][CH:7]=1
KomponentenVersuchsvorschriftQuellen und NachweiseNotizen zur Reaktion

Komponenten

15

Edukt 14

HCID 58275259HCID 58275259, VerbindungHCID 58275351HCID 58275351, VerbindungHCID 58275354HCID 58275354, VerbindungHCID 58275379HCID 58275379, VerbindungHCID 58275476HCID 58275476, VerbindungHCID 67161822
HCID 67161822, Verbindung
HCID 67162433HCID 67162433, Verbindung
HCID 67162584HCID 67162584, Verbindung
HCID 67163129HCID 67163129, Verbindung
HCID 67163310HCID 67163310, Verbindung
HCID 866536144-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide
HCID 866536154-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-2-trifluoromethyl-benzenesulfonamide
HCID 86653616HCID 86653616, Verbindung
HCID 86653617HCID 86653617, Verbindung

Produkt 1

HCID 58275500HCID 58275500, Verbindung

Versuchsvorschrift

4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-3-trifluoromethyl-benzenesulfonamide; 2-Chloro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 2-Chloro-4-{1-[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide; 2-Fluoro-4-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide; 2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 3-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-benzenesulfonamide; 4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-benzenesulfonamide; 4-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-2-trifluoromethyl-benzenesulfonamide; N-(2-Fluoro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide, N-(5-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-2-trifluoromethyl-phenyl)-methanesulfonamide; N-(2-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide; N-(3-Chloro-5-{[6-(4-fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-phenyl)-methanesulfonamide; N-(3-{[6-(4-Fluoro-phenyl)-4-(1-trifluoromethyl-cyclopropylamino)-pyrido[3,2-d]pyrimidin-2-ylamino]-methyl}-5-trifluoromethyl-phenyl)-methanesulfonamide.

Quellen und Nachweise

ORD-Eintrag
ord-98d0c834dbde43a1b53db3864cf37fc4
Quelldatensatz
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08536187B2

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