Sodium Carbonate → 4'-(Methylsulfonyl)-2,4-biphenyldiol

Beteiligte Stoffe

Reaktionsschritte

4′-(Methylsulfonyl)-2,4-biphenyldiol (500 mg, 36%) was prepared as a clear oil from [4-(methylsulfonyl)phenyl]boronic acid (1.06 g, 5.29 mmol), 4-bromo-1,3-benzenediol (1 g, 5.29 mmol), Pd(PPh3)2Cl2 (100 mg, 0.14 mmol), 2M Na2CO3 (5 mL) and DME (5 mL) in a manner similar to Example 21, Step 3. 1H NMR (400 MHz, DMSO-d6) δ 9.68 (s, 1H), 9.52 (s, 1H), 7.88-7.80 (m, 2H), 7.75-7.69 (m, 2H), 7.13 (d, 1H, J=8.4 Hz), 6.41 (d, 1H, J=2.2 Hz), 6.32 (dd, 1H, Ja=8.4 Hz, Jb=2.4 Hz), 3.31 (s, 3H); LRMS (ESI), m/z 263 (M−H).

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