Hydrochloric Acid → 1-(Trifluoromethyl)cyclopropanamine hydrochloride

Reaktionsgleichung

[F:1][C:2]([F:15])([F:14])[C:3]1([NH:6]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1.[ClH:16]>>[ClH:16].[F:1][C:2]([F:15])([F:14])[C:3]1([NH2:6])[CH2:5][CH2:4]1

Komponenten

Edukt 2

HCID 313Hydrochloric Acid

HCID 11658639Tert-butyl [1-(trifluoromethyl)cyclopropyl]carbamate

Produkt 1

HCID 116511961-(Trifluoromethyl)cyclopropanamine hydrochlorideAusbeute 91 %

Versuchsvorschrift

Tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (4.08 g, 18.3 mmol) was suspended in 1 N HCl(aq) (150 mL) and stirred at reflux for 3.5 h. The solution was concentrated in vacuo and the residue was triturated with acetone. The filtrate was collected, concentrated, and the residue triturated with diethyl ether to afford 2.67 g (91%) of 1-(trifluoromethyl)cyclopropylamine hydrochloride as a white solid.

Aufarbeitung

temperatureat reflux for 3.5 h
concentrationThe solution was concentrated in vacuo
customthe residue was triturated with acetone
customThe filtrate was collected
concentrationconcentrated
customthe residue triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag: ord-156c063e1b044551b05abc469f8230ec
Quelldatensatz: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08536187B2

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