Ammonium Chloride → HCID 178462231, Verbindung

HRID 423708Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 423708
[OH:1][C@@H:2]([CH:4]1[CH2:9][CH2:8][N:7]([C:10]#[N:11])[CH2:6][CH2:5]1)[CH3:3].[Cl-].[NH4+].[N-:14]=[N+:15]=[N-:16].[Na+]>CN(C=O)C>[NH:14]1[C:10]([N:7]2[CH2:6][CH2:5][CH:4]([C@H:2]([OH:1])[CH3:3])[CH2:9][CH2:8]2)=[N:11][N:16]=[N:15]1

Komponenten

5

Edukt 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 866387534-[(1R)-1-hydroxyethyl]-1-piperidinecarbonitrile

Produkt 1

HCID 178462231HCID 178462231, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A solution of 4-[(1R)-1-hydroxyethyl]-1-piperidinecarbonitrile (200 mg, 1.30 mmol) in DMF (5 mL) was treated with ammonium chloride (104 mg, 1.95 mmol) and sodium azide (126 mg, 1.95 mmol) at room temperature. The mixture was heated at 100° C. for 14 h. After allowing the mixture to cool, the solid was removed by filtration and washed with DMF. The filtrate was concentrated to give (1R)-1-[1-(1H-tetrazol-5-yl)-4-piperidinyl]ethanol, which was used without further purification.

Aufarbeitung

  1. temperatureto cool
  2. customthe solid was removed by filtration
  3. washwashed with DMF
  4. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-f279832174a74669bc6b866c75fe8482
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08101634B2

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