2,5-Dichlorothiophene-3-sulfonyl chloride → 2,5-Dichloro-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-3-sulfonamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2,5-Dichlorothiophene-3-sulfonyl chloride	HCID 2736094	—
Edukt	5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine	HCID 59386306	—
Produkt	2,5-Dichloro-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-3-sulfonamide	HCID 56953321	—

Reaktionsschritte

According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene1,2-diamine was reacted with 2,5-dichlorothiophene-3-sulfonyl chloride to obtain the title compound. 1H NMR (300 MHz, CDCl3): δ 7.41 (dd, J=1.5 & 10.5 Hz, 1H), 7.28-7.20 (m, 2H), 7.08 (dd, J=9.0 & 17.4 Hz, 2H), 6.99 (s, 1H), 6.03 (dt, J=2.1, 8.7 & 17.4 Hz, 1H), 5.56 (br s, 1H).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08101799B2
Quelldatensatz	uspto-grants-2012_01
ORD ID	ord-ce9f8b0c4f224fe28e9dc27c57cce7e0
Quellennotiz	uspto-grants-2012_01