erythro-N-Boc-D-phenylalanine epoxide → [(1R,2S)-1-Benzyl-2-hydroxy-3-[1,2,3]triazol-1-yl-propyl]-carbamic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:19])[NH:7][C@@H:8]([C@@H:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[NH:20]1[CH:24]=[CH:23][N:22]=[N:21]1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C@@H:16]([OH:17])[CH2:18][N:20]1[CH:24]=[CH:23][N:22]=[N:21]1)([CH3:4])([CH3:3])[CH3:2]Komponenten
3
Versuchsvorschrift
Using general procedure 4 and purification method E with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.15 g, 0.57 mmol) and 1,2,3-triazole (0.037 mL, 0.63 mmol) gives the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-bbf6fc2ace2a4d4fb2924e948fc236d5
- Quelldatensatz
- uspto-grants-2012_01