Aluminum(III) Chloride → 1-(4-Chloro-2-hydroxyphenyl)ethanone
Reaktionsgleichung
[OH:1][C:2]1[CH:7]=[C:6](OC(C(OCC)=O)(C)C)[CH:5]=[CH:4][C:3]=1[C:17](=[O:19])[CH3:18].[Cl-:20].[Al+3].[Cl-].[Cl-]>>[Cl:20][C:6]1[CH:5]=[CH:4][C:3]([C:17](=[O:19])[CH3:18])=[C:2]([OH:1])[CH:7]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 200 °C
Versuchsvorschrift
3-chlorophenyl acetate (starting material 2) was mixed with aluminium chloride (3 eq). The mixture was heated at 200° C. for 1 hour. The reaction medium was cooled. to room temperature then poured in ice. The aqueous phase was extracted with methylene chloride which was dried on magnesium sulfate then vacuum evaporated.
Aufarbeitung
- temperatureThe reaction medium was cooled
- additionto room temperature then poured in ice
- extractionThe aqueous phase was extracted with methylene chloride which
- customwas dried on magnesium sulfate
- customvacuum evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-d63a34b3f064470a8369c2b0156b97c1
- Quelldatensatz
- uspto-grants-2012_01
- Patentnummer
- US08106097B2
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