Nitric Acid → HCID 66703994, Verbindung
Reaktionsgleichung
[C:1]([NH:4][C:5]1[CH:14]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:21])[CH:11]=2)[N:6]=1)(=[O:3])[CH3:2].[N+:22]([O-])([OH:24])=[O:23]>>[C:1]([NH:4][C:5]1[CH:14]=[C:13]([C:15]2[CH:16]=[CH:17][C:18]([N+:22]([O-:24])=[O:23])=[CH:19][CH:20]=2)[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([Cl:21])[CH:11]=2)[N:6]=1)(=[O:3])[CH3:2]Komponenten
3
Versuchsvorschrift
200 mg of 2-acetylamino-6-chloro-4-phenylquinoline were introduced in portions into 4 ml of 100% strength HNO3 at 0° C. and stirred at 0° C. to 5° C. for 30 min, and the reaction mixture was poured into ice-water. Neutralization with 2N NaOH was followed by extraction with ethyl acetate and removal of the solvent by distillation. The solid residue was boiled several times with diisopropyl ether, and the solvent of the filtrate was evaporated until the substance separated out as crystals.
Aufarbeitung
- extractionNeutralization with 2N NaOH was followed by extraction with ethyl acetate and removal of the solvent by distillation
- customthe solvent of the filtrate was evaporated until the substance
- customseparated out as crystals