Hydrochloric Acid → HCID 178442437, Verbindung
Reaktionsgleichung
Cl.C(OC(=O)[NH:8][C:9]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([NH:33][C:34](=[O:36])[CH3:35])[C:22]3[NH:23][CH:24]=[C:25]([CH2:27][C:28]([CH3:32])([CH3:31])[CH2:29][CH3:30])[N:26]=3)=[CH:16][CH:15]=2)=[CH:12][N:11]([CH3:37])[N:10]=1)(C)(C)C>CO>[NH2:8][C:9]1[C:13]([C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH:21]([NH:33][C:34](=[O:36])[CH3:35])[C:22]3[NH:23][CH:24]=[C:25]([CH2:27][C:28]([CH3:32])([CH3:31])[CH2:29][CH3:30])[N:26]=3)=[CH:18][CH:19]=2)=[CH:12][N:11]([CH3:37])[N:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
Hydrogen chloride (4 M in 1,4-dioxane) (1 mL, 4 mmol) was added to an ambient temperature solution of tert-butyl[4-(4-{2-(acetylamino)-2-[4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]ethyl}phenyl)-1-methyl-1H-pyrazol-3-yl]carbamate (Example 51) (4.2 mg, 0.01 mmol) in methanol (2 mL). After stirring at 70° C. for 1 h, volatiles were removed in vacuo. The residue was partitioned between methanol/ethyl acetate and 10% aqueous sodium hydroxide. The aqueous phase was extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulfate) and concentrated in vacuo to afford the title compound. (M+H) found: 409.