Ethyl trifluoroacetate → (1S,2S,5R)-2-[(2,2,2-trifluoro-acetylamino)-methyl]-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester

HRID 425799Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 425799
[F:1][C:2]([F:9])([F:8])[C:3]([O:5]CC)=O.[C:10]([O:14][C:15]([N:17]1[CH2:24][C@H:23]2[C@H:19]([CH2:20][CH:21]([CH3:25])[CH2:22]2)[C@H:18]1[CH2:26][NH2:27])=[O:16])([CH3:13])([CH3:12])[CH3:11]>C1COCC1>[C:10]([O:14][C:15]([N:17]1[CH2:24][C@H:23]2[C@H:19]([CH2:20][CH:21]([CH3:25])[CH2:22]2)[C@H:18]1[CH2:26][NH:27][C:3](=[O:5])[C:2]([F:1])([F:8])[F:9])=[O:16])([CH3:12])([CH3:13])[CH3:11]

Komponenten

4

Edukt 2

HCID 9794Ethyl trifluoroacetateHCID 59411604(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester

Produkt 1

HCID 86643543(1S,2S,5R)-2-[(2,2,2-trifluoro-acetylamino)-methyl]-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Ethyl trifluoroacetate (0.7 mL, 1.4 eq) was added to a solution of (1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester (1.1 g) in dry THF (14 mL). The reaction mixture was stirred at RT for 1 h. Solvent and excess ethyl trifluoroacetate were evaporated in vacuo. The resulting product was then used for the next step without purification

Aufarbeitung

  1. customSolvent and excess ethyl trifluoroacetate were evaporated in vacuo
  2. customThe resulting product was then used for the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-8a7c1d34377e492a85e0fbc3ecbd2260
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08106215B2

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