Trifluoroacetic acid → N-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-2,2,2-trifluoro-acetamide

HRID 425800Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 425800
C(OC([N:8]1[CH2:15][C@H:14]2[C@H:10]([CH2:11][CH:12]([CH3:16])[CH2:13]2)[C@H:9]1[CH2:17][NH:18][C:19](=[O:24])[C:20]([F:23])([F:22])[F:21])=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:16][CH:12]1[CH2:11][C@H:10]2[C@H:14]([CH2:15][NH:8][C@@H:9]2[CH2:17][NH:18][C:19](=[O:24])[C:20]([F:23])([F:21])[F:22])[CH2:13]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86643543(1S,2S,5R)-2-[(2,2,2-trifluoro-acetylamino)-methyl]-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester

Produkt 1

HCID 86643544N-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-2,2,2-trifluoro-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a cold (0° C.) solution of (1S,2S,5R)-2-[(2,2,2-trifluoro-acetylamino)-methyl]-7-methyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid tert.-butyl ester (1.51 g) in DCM (13 mL) was slowly added TFA (3.31 mL, 10 eq). The reaction mixture was allowed to warm at RT and stirred overnight. Solvent and excess of TFA were removed in vacuo and the product was used for the next step without further purification.

Aufarbeitung

  1. customSolvent and excess of TFA were removed in vacuo
  2. customthe product was used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-09f31d8d967e47e9a5c4fb78cc1b43ed
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08106215B2

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