Dimethylformamide → 3,5-Dimethylbenzamide

HRID 426288

Reaktionsgleichung

Reaktionsgleichung von HRID 426288
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](O)=[O:6].C[N:13](C=O)C>S(Cl)(Cl)=O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5]([NH2:13])=[O:6]

Komponenten

4

Edukt 2

HCID 6228DimethylformamideHCID 103563,5-Dimethylbenzoic acid

Produkt 1

HCID 3194853,5-DimethylbenzamideAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24386Thionyl ChlorideLösungsmittel

Versuchsvorschrift

3,5-Dimethylbenzoic acid (50 g, 0.33 M, Aldrich) was suspended in thionyl chloride (150 mL) and DMF (0.5 mL) was added. The mixture was then refluxed for 2.5 hr. Excess thionyl chloride was evaporated in vacuo and the residue was added dropwise to ammonium hydroxide solution (ACS, 250 ml) cooled in an ice bath. The mixture was stirred for further 30 min. The white precipitate was then filtered, washed with water several times, and dried by standing on air. The crude product was dissolved in MC, washed with water, dried with anhydrous magnesium sulfate, filtered, and evaporated in vacuo to afford 42 g (85%) of 3,5-dimethylbenzamide as a white solid. m.p. 148-149° C. 1H NMR (200 MHz, CDCl3) δ 2.35 (6H, s), 6.01 (2H, br. s), 7.15 (1H, s), 7.42 (2H, s).

Aufarbeitung

  1. temperatureThe mixture was then refluxed for 2.5 hr
  2. customExcess thionyl chloride was evaporated in vacuo
  3. additionthe residue was added dropwise to ammonium hydroxide solution (ACS, 250 ml)
  4. temperaturecooled in an ice bath
  5. filtrationThe white precipitate was then filtered
  6. washwashed with water several times
  7. customdried
  8. dissolutionThe crude product was dissolved in MC
  9. washwashed with water
  10. dry with materialdried with anhydrous magnesium sulfate
  11. filtrationfiltered
  12. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-33ba519876824387b66049e427ae085c
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08106064B2

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