Acetonitrile → N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-furansulfonamide

HRID 426445

Reaktionsgleichung

Reaktionsgleichung von HRID 426445
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([N:9]=[C:10]=[O:11])(=[O:8])=[O:7].[NH2:12][C:13]1[N:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([CH3:21])[N:14]=1.C(#N)C>C(Cl)Cl>[CH3:20][O:19][C:17]1[CH:16]=[C:15]([CH3:21])[N:14]=[C:13]([NH:12][C:10]([NH:9][S:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)(=[O:7])=[O:8])=[O:11])[N:18]=1

Komponenten

5

Edukt 3

HCID 6342AcetonitrileHCID 5872364-Methoxy-6-methylpyrimidin-2-amineHCID 233424782-Furansulfonyl isocyanate

Produkt 1

HCID 20390812N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-furansulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 2.10 g of 2-furansulfonyl isocyanate in 40 ml of methylene chloride was added 1.60 g 2-amino-4-methoxy-6-methylpyrimidine. The resulting mixture was stirred for 1 hour at room temperature, then refluxed for 15 minutes, and the solvent was removed under vacuum. The solid obtained was allowed to stand under ethyl ether containing a trace of acetonitrile for one day, and was then filtered and dried to give the desired product melting at 185°-188° (dec).

Aufarbeitung

  1. temperaturerefluxed for 15 minutes
  2. customthe solvent was removed under vacuum
  3. customThe solid obtained
  4. customfor one day
  5. filtrationwas then filtered
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e008343bb5c146f7a23cf3c4aa20f90c
Quelldatensatz
uspto-grants-1979_10
Patentnummer
US04169719

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