Ethanol → Trifluoromethyl toluidine

HRID 427004

Reaktionsgleichung

Reaktionsgleichung von HRID 427004
[NH2:1][C:2]1[C:3]([CH2:13]SC)=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1Cl.C(O)C>[OH-].[K+].[Ni]>[NH2:1][C:2]1[C:3]([CH3:13])=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 702EthanolHCID 233529853-Amino-4-chloro-2-methylthiomethylbenzotrifluoride

Produkt 1

HCID 2735932Trifluoromethyl toluidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 14797Potassium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

Dissolve 2 g. of 3-amino-4-chloro-2-methylthiomethylbenzotrifluoride in 50 ml. of 90% ethanol which is 1N in potassium hydroxide. Add 2 teaspoonsful of Raney nickel (W-2). Stir at 70° C. for 3 hours, cool and filter. Add 50 ml. of water and extract three times with hexane. Dry the combined organic extracts and evaporate to yield the title compound.

Aufarbeitung

  1. dissolutionDissolve 2 g
  2. temperaturecool
  3. filtrationfilter
  4. additionAdd 50 ml
  5. extractionof water and extract three times with hexane
  6. customDry the combined organic extracts
  7. customevaporate

Quellen und Nachweise

ORD-Eintrag
ord-392def21d91848d499a8551560e39e13
Quelldatensatz
uspto-grants-1979_10
Patentnummer
US04172095

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