Isobutylamine → Boc-Ile-NH-CH2-CH(CH3)2

Beteiligte Stoffe

Reaktionsschritte

In a DMF solution containing 2.0 g of Boc-Ile-OH, 0.82 ml of isobutylamine, 1.27 g of HOBt and 2.06 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture, after filtration, was treated similarly to that in Example 50 (Process 2), except for the crystallization solvent (hexane) to give 1.44 g of the title compound.

Herkunft & Nachweise