Isobutylamine → Boc-Ile-NH-CH2-CH(CH3)2

HRID 427360

Reaktionsgleichung

Reaktionsgleichung von HRID 427360
[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([OH:9])=O)[C@H:3]([CH2:5][CH3:6])[CH3:4].[CH2:17]([NH2:21])[CH:18]([CH3:20])[CH3:19].C1C=CC2N(O)N=NC=2C=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C=O)C>[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([NH:21][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:9])[C@H:3]([CH2:5][CH3:6])[CH3:4]

Komponenten

6

Edukt 4

HCID 6558IsobutylamineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 2724762tert-Butoxycarbonyl-L-isoleucine

Produkt 1

HCID 131722955Boc-Ile-NH-CH2-CH(CH3)2

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

In a DMF solution containing 2.0 g of Boc-Ile-OH, 0.82 ml of isobutylamine, 1.27 g of HOBt and 2.06 g of DCC were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture, after filtration, was treated similarly to that in Example 50 (Process 2), except for the crystallization solvent (hexane) to give 1.44 g of the title compound.

Aufarbeitung

  1. additionwere added under ice cooling
  2. filtrationThe reaction mixture, after filtration
  3. additionwas treated similarly to that in Example 50 (Process 2)

Quellen und Nachweise

ORD-Eintrag
ord-f043d0260b1949569a14578a54763201
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313094B1

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