4'-Fluoroacetophenone → 1-(4-Acetylphenyl)-4-(4-pyridyl)piperazine

HRID 427456

Reaktionsgleichung

[C:1]([C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[CH2:19][CH2:18]2)=[CH:13][CH:12]=1)(=[O:10])[CH:2]=CC1C=CC=CC=1.CC(C1C=CC(F)=CC=1)=O.FC1C=CC(C(C2C=CC=CC=2)=O)=CC=1>>[C:1]([C:11]1[CH:12]=[CH:13][C:14]([N:17]2[CH2:18][CH2:19][N:20]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[CH2:21][CH2:22]2)=[CH:15][CH:16]=1)(=[O:10])[CH3:2]

Komponenten

Edukt 3

HCID 98284'-Fluoroacetophenone

HCID 676634-Fluorobenzophenone

HCID 536791701-(4-Cinnamoylphenyl)-4-(4-pyridyl)piperazine

Produkt 1

HCID 183571351-(4-Acetylphenyl)-4-(4-pyridyl)piperazineAusbeute 40 %

Versuchsvorschrift

The 1-(4-acetylphenyl)-4-(4-pyridyl)piperazine used as starting material was prepared as in Example 32, using 4-fluoroacetophenone as starting material in place of 4-fluorobenzophenone to give 1-(4-acetylphenyl)-4-(4-pyridyl)piperazine (40% yield), m.p. 176-177° C.

Aufarbeitung

customwas prepared as in Example 32

Quellen und Nachweise

ORD-Eintrag: ord-56cc5e7890734fd8bc4174e1de91c4cf
Quelldatensatz: uspto-grants-2001_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06313127B1

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