Potassium Hydroxide → 4-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridine

HRID 427458

Reaktionsgleichung

Reaktionsgleichung von HRID 427458
[C:1]([C:3]1[CH:20]=[CH:19][C:6]([O:7][CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:9]2)=[CH:5][CH:4]=1)#[N:2].[OH-:21].[K+]>C(O)(C)(C)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:7][CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:9]2)=[CH:19][CH:20]=1)(=[O:21])[NH2:2]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 183570874-[3-(4-Cyanophenoxy)-1-pyrrolidinyl]pyridine

Produkt 1

HCID 183571004-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridineAusbeute 57,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

A mixture of 4-[3-(4-cyanophenoxy)-1-pyrrolidinyl]pyridine (269 mg) and powdered potassium hydroxide (568 mg) in t-butanol (10 ml), under an atmosphere of argon, was heated under reflux for 18 hours. The mixture was filtered hot. The filtercake was washed with water and ethanol to give 4-[3-(4-carbamoylphenoxy)-1-pyrrolidinyl]pyridine (166 mg) as a colourless solid, mp 298-300° C.

Aufarbeitung

  1. temperatureunder an atmosphere of argon, was heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe mixture was filtered hot
  4. washThe filtercake was washed with water and ethanol

Quellen und Nachweise

ORD-Eintrag
ord-1c442b2f30054d8ab9cea61c32b9e4d3
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313127B1

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