Ethyl 2-chloroacetoacetate → Ethyl 8-amino-6-(aminocarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carboxylate

HRID 427506Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 427506
[NH2:1][C:2]1[C:3]([NH2:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8].[CH2:12]([O:14][C:15](=[O:21])[CH:16](Cl)[C:17]([CH3:19])=O)[CH3:13]>C(O)C>[NH2:1][C:2]1[C:3]2[N:4]([C:16]([C:15]([O:14][CH2:12][CH3:13])=[O:21])=[C:17]([CH3:19])[N:11]=2)[CH:5]=[C:6]([C:7]([NH2:9])=[O:8])[CH:10]=1

Komponenten

4

Edukt 2

HCID 11858Ethyl 2-chloroacetoacetateHCID 99421905,6-Diaminonicotinamide

Produkt 1

HCID 18357447Ethyl 8-amino-6-(aminocarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carboxylateAusbeute 12 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5,6-Diaminonicotinamide (2.0 g, 13.4 mmol), ethyl-2-chloroacetoacetate (2.38 g, 14.4 mmol) and ethanol (40 ml) were refluxed for 20 h. The precipitate was isolated by filtration and washed with ethanol and diethyl ether. The solids were suspended in water, basified with a sodium hydroxide solution and isolated by filtration. Washing the solids with water and diethyl ether gave 0.42 g (12%) of the desired product.

Aufarbeitung

  1. customThe precipitate was isolated by filtration
  2. washwashed with ethanol and diethyl ether
  3. customisolated by filtration
  4. washWashing the solids with water and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-2b22776d263345f19074e980817f6d80
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313137B1

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