Sodium Hydroxide → 2-[N-(5-Bromo-2-hydroxybenzyl)-N-ethylamino]pyridine-5-carboxylic Acid

Temperatur

40 °C

A solution of methyl 2-[N-(5-bromo-2-hydroxybenzyl)-N-ethylamino]pyridine-5-carboxylate (see reference example 6) (10.2 g, 0.55 mmol) in THF (3 ml) and methanol (5 ml) was treated with 1N aqueous sodium hydroxide solution (2.7 ml) and was heated to 40° C. for 24 hours. The solvents were evaporated at reduced pressure, the residue treated with 1N acetic acid (2.7 ml) and the precipitate filtered, washed with water and air dried to give the title compound (0.17 g, 92%).

1. customThe solvents were evaporated at reduced pressure
2. additionthe residue treated with 1N acetic acid (2.7 ml)
3. filtrationthe precipitate filtered
4. washwashed with water and air
5. customdried

ORD-Eintrag

ord-d1b03431f5ca4525bfe5da543312b6bf

Quelldatensatz

uspto-grants-2001_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06313148B1