Indole → 1H-Indole, 1-(1-methoxyethyl)-

To a suspension of NaH (1.92 gm of a 60% dispersion in oil) in 75 mL of DMF was added indole (4.68 gm, 40 mmol) (Aldrich). The mixture was stirred for 15 minutes at 0° C., and 1-chloroethyl methylether (4 mL) was added dropwise. The resulting mixture was stirred at 0° C. for 1 hour and poured over ice/water, and extracted with toluene. The organic layer was dried over magnesium sulfate, and evaporated. The residue was purified by flash chromatography using EtOAc/hexanes to give 4 gm of 1-[1-methoxyethyl]indole. (Yield 58%).

1. stirringThe resulting mixture was stirred at 0° C. for 1 hour
2. extractionextracted with toluene
3. dry with materialThe organic layer was dried over magnesium sulfate
4. customevaporated
5. customThe residue was purified by flash chromatography

ORD-Eintrag

ord-fda5e46a6cce4fcdb4ebce9c540d39c0

Quelldatensatz

uspto-grants-2001_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06313143B1