methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]ethyl]phenoxy]acetate → (E)-N-[3-[(methyl-carbamoyl) methoxy]phenethyl]-3-(3-pyridyl)-2-propenoic acid amide

HRID 428136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 428136
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](/[CH:7]=[CH:8]/[C:9]([NH:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([CH:23]=[CH:24][CH:25]=2)[O:17][CH2:18][C:19]([O:21]C)=O)=[O:10])[CH:2]=1.[CH3:26][NH2:27].CO>CO>[CH3:26][NH:27][C:19]([CH2:18][O:17][C:16]1[CH:15]=[C:14]([CH:25]=[CH:24][CH:23]=1)[CH2:13][CH2:12][NH:11][C:9](=[O:10])/[CH:8]=[CH:7]/[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)=[O:21]

Komponenten

4

Edukt 2

HCID 20701346methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]ethyl]phenoxy]acetateHCID 57454252Monomethylamine methanol

Produkt 1

HCID 20701410(E)-N-[3-[(methyl-carbamoyl) methoxy]phenethyl]-3-(3-pyridyl)-2-propenoic acid amideAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl [3-[2-[(E)-3-(3-pyridyl)acryloylamino]-ethyl]phenoxy]acetate (0.34 g, 1.0 mmol) obtained in Example 94 was dissolved in methanol (6 ml) and 40% methylamine-methanol solution (0.8 ml) was added and stirred at room temperature for 17 hours. After concentrating the reaction mixture under reduced pressure, the residue was recrystallized to yield the titled compound (0.30 g, 88%).

Aufarbeitung

  1. concentrationAfter concentrating the reaction mixture under reduced pressure
  2. customthe residue was recrystallized

Quellen und Nachweise

ORD-Eintrag
ord-79678c02d7cc454e9768d133289dce14
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313153B1

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