2,7-Dimethoxy-1-naphthaldehyde → 2-Hydroxy-7-methoxy-1-naphthaldehyde

HRID 428153Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 428153
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([O:13][CH3:14])=[CH:8][CH:9]=2)[C:4]=1[CH:15]=[O:16].C(=O)([O-])O.[Na+]>ClCCl>[OH:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][C:7]([O:13][CH3:14])=[CH:8][CH:9]=2)[C:4]=1[CH:15]=[O:16]

Komponenten

4

Edukt 2

HCID 2932152,7-Dimethoxy-1-naphthaldehydeHCID 516892Sodium Bicarbonate

Produkt 1

HCID 105360972-Hydroxy-7-methoxy-1-naphthaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

After the dimethoxylated product obtained in Step B (2 g:9.25 mmol) has been dissolved in anhydrous dichloromethane, 97% BBr3Me2S complex (2.98 g:9.25 mmol:1 eq.) is introduced at ambient temperature. After 35 minutes of stirring, hydrolysis is carried out with a saturated solution of sodium hydrogen carbonate (pH=8). The product is extracted with dichloromethane and then purified on a silica column AcOEt/PE (3/7).

Aufarbeitung

  1. addition97% BBr3Me2S complex (2.98 g:9.25 mmol:1 eq.) is introduced at ambient temperature
  2. customhydrolysis
  3. extractionThe product is extracted with dichloromethane
  4. custompurified on a silica column AcOEt/PE (3/7)

Quellen und Nachweise

ORD-Eintrag
ord-4b095e46f6eb4ea897f9a95701f82c92
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313160B1

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