Acrylonitrile → 3-(4-Methoxyphenoxy)propanenitrile

HRID 428176

Reaktionsgleichung

Reaktionsgleichung von HRID 428176
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[C:10](#[N:13])[CH:11]=[CH2:12]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:12][CH2:11][C:10]#[N:13])=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 7855AcrylonitrileHCID 90154-Methoxyphenol

Produkt 1

HCID 1142473-(4-Methoxyphenoxy)propanenitrile

Versuchsvorschrift

A mixture of 4-methoxyphenol (10 g:80.5 mmol) and Triton B (2.29 ml:14.5 mmol 0. 18 eq.) in acrylonitrile (50 ml) is heated at reflux for 48 hours. After the solvent has been partially removed, the products are extracted with ethyl acetate and washed with water and then with a 6N hydrochloric acid solution. The residual chestnut-brown oil is purified on a flash silica column eluted with an AcOEt/PE gradient.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux for 48 hours
  3. customAfter the solvent has been partially removed
  4. extractionthe products are extracted with ethyl acetate
  5. washwashed with water
  6. customThe residual chestnut-brown oil is purified on a flash silica column
  7. washeluted with an AcOEt/PE gradient

Quellen und Nachweise

ORD-Eintrag
ord-30a09853878a43d3afd334255626989d
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06313160B1

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