Indole → 3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole

Beteiligte Stoffe

Reaktionsschritte

Indole (4.69, 40 mmol), 1,4-cyclohexanedione monoethylene ketal (6.3 g, 40 mmol) and potassium hydroxide (13.2 g, 200 mmol) were heated to reflux in 70 ml methanol for 6 hours. The reaction was cooled and the product was isolated by filtration and washed with water to give 9.1 g (89%) of product.

Herkunft & Nachweise