HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 429Erstellt: 23. Oktober 2026
1-(Benzyloxy)-3-bromobenzene → 2-Methyl-1-(3-phenylmethoxyphenyl)-6-(trifluoromethoxy)indole
https://huagongshe.com/de/reaction/429
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-(Benzyloxy)-3-bromobenzene | HCID 2756638 | — |
| Edukt | 2-Methyl-6-(trifluoromethoxy)-1H-indole | HCID 12180669 | — |
| Reagenz | Sodium t-butoxide | HCID 23676156 | — |
| Katalysator | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| Katalysator | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 2-Methyl-1-(3-phenylmethoxyphenyl)-6-(trifluoromethoxy)indole | HCID 59216720 | 59,07% |
Reaktionsschritte
EN04773-53, _Buchwald coupling, toluene and bromide_ The indole from 4773-25, 1-(benzyloxy)-3-bromobenzene,Pd2(dba)3, JohnPhos and KOtBu were dissolved in toluene. The mixture was warmed at 100 °C for 2h. Ca 60% conversion according to LCMS (product at 2.31 min). This conversion rate seemed faster than for the corresponding aryliodide. Big bacth was performed in 4773-54.
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-0addbbece6dc4ca2acdd8d8c9131d423 |
|---|
| Quellennotiz | 750 AstraZeneca ELN dataset |
|---|
